Daily scheduled airline flights serve Iqaluit and connect to all major Canadian cities and Greenland. Three of Canada's major airlines, Air Canada, Canadian North, First Air and Air Labrador operate scheduled service on the following routes:

• Ottawa - Iqaluit (Canadian, connecting to Toronto)
• Montreal - Iqaluit (First Air, connecting to Toronto)
• Winnipeg-Rankin Inlet-Iqaluit (First Air)
• Edmonton-Yellowknife-Rankin Inlet-Iqaluit (Canadian, First Air, Air Canada, connecting to Vancouver)